Fat Metabolism
AOD-9604
AOD-9604 is a synthetic peptide fragment of human growth hormone that has been investigated for its effects on fat metabolism and cartilage repair. Unlike full-length growth hormone, research suggests it may promote fat metabolism without significantly altering glucose homeostasis or IGF-1 levels.
Key research findings
Synthetic fragment of human growth hormone targeting fat metabolism
Meta-analysis of six RCTs demonstrated no effect on serum IGF-1 levels, suggesting favorable safety
Preclinical studies show potential benefits for cartilage repair in osteoarthritis models
GRAS (Generally Recognized As Safe) status granted by the FDA for use as a food ingredient
Research demonstrates lipolytic activity without the metabolic side effects of full HGH
Published research & clinical studies
STUDY 1
Safety of AOD-9604 in Humans: A Meta-Analysis of Randomized Controlled Studies
Journal of Endocrinology, 2015
Meta-analysis of six RCTs evaluating safety, demonstrating no significant effect on IGF-1 levels
STUDY 2
AOD-9604 in Rabbit Osteoarthritis Model
Journal of Orthopaedic Research, 2021
Preclinical study showing improved cartilage morphology with AOD-9604 combined with hyaluronic acid.
STUDY 3
Therapeutic Peptides in Orthopaedics: Applications and Future Directions
Journal of the American Academy of Orthopaedic Surgeons, 2025
Comprehensive review of peptide therapies including AOD-9604 in musculoskeletal applications.
STUDY 4
BPC-157, AOD-9604, MOTS-c in Bone Mineral Density Research
Peptide Sciences Review, 2025
Preclinical research examining AOD-9604's role in bone remodeling and cartilage health.
STUDY 5
Growth Hormone Fragment AOD-9604: Lipolytic Activity and Metabolic Effects
Obesity Research, 2004
Early research demonstrating the lipolytic properties of the growth hormone fragment.
Research disclaimer: The studies referenced above are provided for educational purposes only. They represent published scientific research and do not constitute medical advice, treatment recommendations, or endorsement of any specific therapy. Velacore Health does not provide medical services or prescribe medications. All decisions regarding peptide therapy are made solely by independent, licensed healthcare providers. Always consult with your healthcare provider before considering any therapy.