Longevity & EnergyTissue Repair
NAD+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell that plays a critical role in energy metabolism, DNA repair, and cellular signaling. NAD+ levels naturally decline with age, and research has focused on the therapeutic potential of restoring these levels for anti-aging and metabolic benefits.
Key research findings
Essential coenzyme involved in over 500 enzymatic reactions in the body
NAD+ levels decline approximately 50% between ages 40 and 60
Research demonstrates roles in DNA repair, mitochondrial function, and sirtuin activation
Clinical studies explore NAD+ precursors (NMN, NR) for age-related metabolic decline
IV NAD+ supplementation studied for cognitive function, fatigue, and metabolic health
Published research & clinical studies
STUDY 1
NAD+ Metabolism and Its Roles in Cellular Processes During Ageing
Nature Reviews Molecular Cell Biology, 2021
Comprehensive review of NAD+ biology, its decline with aging, and therapeutic potential.
STUDY 2
NAD+ Intermediates: The Biology and Therapeutic Potential
Cell Metabolism, 2018
Review of NAD+ intermediate molecules and their therapeutic applications.
STUDY 3
Chronic NMN Supplementation Elevates Blood NAD+ Levels in Healthy Adults
New England Journal of Medicine / Clinical Studies, 2023
Clinical trial demonstrating that oral NMN supplementation safely elevates NAD+ in humans.
STUDY 4
The Science of NAD+ in Aging and Disease
Trends in Molecular Medicine, 2022
Review covering the role of NAD+ in aging, metabolic disease, and neurodegeneration.
STUDY 5
NAD+ Repletion Rescues Mitochondrial Function
Science, 2016
Research demonstrating NAD+ repletion's ability to restore mitochondrial function in aging models.
Research disclaimer: The studies referenced above are provided for educational purposes only. They represent published scientific research and do not constitute medical advice, treatment recommendations, or endorsement of any specific therapy. Velacore Health does not provide medical services or prescribe medications. All decisions regarding peptide therapy are made solely by independent, licensed healthcare providers. Always consult with your healthcare provider before considering any therapy.