Cognitive Performance
Semax
Semax is a synthetic heptapeptide analog of ACTH (adrenocorticotropic hormone) that has been extensively studied in Russia for cognitive enhancement and neuroprotection. Research has focused on its ability to increase brain-derived neurotrophic factor (BDNF) and modulate neurotransmitter systems related to focus, memory, and neuroprotection.
Key research findings
Synthetic analog of ACTH fragment (4-10) with added Pro-Gly-Pro sequence
Research demonstrates increased BDNF expression in the brain
Studied for neuroprotective effects in stroke and neurodegenerative conditions
Modulates dopaminergic and serotonergic neurotransmitter systems
Approved in Russia as a prescription medication for cognitive and neurological conditions to direct growth hormone administration
Published research & clinical studies
STUDY 1
Semax: Mechanisms of Neuroprotective Action
Doklady Biological Sciences, 2006
Research on the neuroprotective mechanisms of semax including BDNF modulation.
STUDY 2
Semax Effects on the Expression of Genes Related to the Immune and Vascular Systems
BMC Genomics, 2014
Genomic study revealing semax's effects on immune and vascular gene expression after stroke.
STUDY 3
ACTH(4-10) Analogue Semax and Neurotrophin Expression
Neuroscience Letters, 2011
Research on semax's stimulation of neurotrophin expression including BDNF and NGF.
STUDY 4
Neuroactive Peptides Including Semax in Neuroplasticity
JAAOS / PMC, 2025
Review covering semax alongside other neuroactive peptides for BDNF and neuroplasticity.
STUDY 5
Pharmacological Effects of Semax on the Central Nervous System
Russian Journal of Bioorganic Chemistry, 2008
Comprehensive review of semax's pharmacological effects on CNS function.
Research disclaimer: The studies referenced above are provided for educational purposes only. They represent published scientific research and do not constitute medical advice, treatment recommendations, or endorsement of any specific therapy. Velacore Health does not provide medical services or prescribe medications. All decisions regarding peptide therapy are made solely by independent, licensed healthcare providers. Always consult with your healthcare provider before considering any therapy.